On March 14, 2025, the Academy sent a letter to the National Science Foundation (NSF) in response to their February 6, 2025, request for information on developing an artificial intelligence (AI) action plan. The letter emphasized the importance of properly addressing ethical issues related to AI use, the impact of AI on patients, providers, and system burdens, the need for data accuracy, validity, and reliability, and the necessity of research investments to monitor the impact of deployed AI.

On March 7, 2025, the Academy sent a letter to the Department of Health and Human Services (HHS) regarding the proposed rule to modify the HIPAA Security Rule to strengthen the cybersecurity of electronic protected health information (ePHI). The letter highlighted the need to support cybersecurity measures in conjunction with sustainable patient care flows, address care that occurs outside of traditional settings, and clarify the application of the rule to current and emergent AI technologies. The Academy’s Artificial Intelligence Taskforce along with the Informatics & Technology and Bioethics Expert Panels contributed to the development of the response. 

On May 3, 2024, the Academy sent a letter to the National Academy of Medicine's Artificial Intelligence Code of Conduct Project Steering Committee regarding their request for information on Artificial Intelligence in Health, Health Care, and Biomedical Science: An AI Code of Conduct Principles and Commitments Discussion Draft.

On April 3, 2020, the Academy provided input and recommendations to the Office of the National Coordinator for Health Information Technology regarding their draft 2020-2025 Federal Health Information Technology (Health IT) Strategic Plan. The Academy’s comments emphasized that critical components should be explored to evaluate AI’s impact on health equity; consider ethical issues in regulatory initiatives; invest in AI research; reduce regulatory burdens on daily practice for providers, secure patient privacy protections, evaluate the integration of AI within the broader Health IT infrastructure; and ensure that the development of AI applications includes clear guidance to ensure privacy and transparency of data use related to personal health information.

On March 13, 2020, the Academy provided feedback to the Office of Management and Budget (OMB) on a draft memorandum to the Heads of Executive Departments and Agencies, Guidance for Regulation of Artificial Intelligence Applications. The Academy recommended broadening the concept around the use of AI related to social goals; including attention to ethical issues in all regulatory initiatives related to AI; including an emphasis and investment in research; including data accuracy, validity, and reliability in the evaluation of the risks, benefits, and cost of AI; and clarifying guidance related to the use of personal health information.